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Genomvisc

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Genomvisc

Sodium Hyaluronate EP 15mg

Phosphate Buffer Saline q.s.

Hyaluronic acid, also called hyaluronan or hyaluronate is a gel-like substance that is naturally present throughout the human body. In the joints, natural hyaluronic acid has several functions.

  • Approved use of hyaluronic acid The US Food and Drug Administration (FDA) approves the use of hyaluronic acid injections for treating knee osteoarthritis.
  • Effects on knee pain and inflammation Hyaluronic acid injections may reduce knee osteoarthritic symptoms by one or more of its following properties:
  • Lubrication In some people, the viscosity of hyaluronic acid may provide better lubrication and shock absorption in the knee joint. These effects may reduce friction within the joint, thereby reducing pain and stiffness, and preventing the loss of cartilage and bone.
  • Anti-inflammatory effects Research shows hyaluronic acid injections may provide anti-inflammatory effects such as reduced pain, inflammation, and/or swelling in the knee.
  • Pain-relieving effects In some people, hyaluronic acid molecules form a boundary around nerve endings, preventing pain signals from being sent to the brain. These molecules also bind to other cells in the knee that signal pain. Through these mechanisms, knee pain may be decreased.

The viscosity of hyaluronic acid may also have positive effects on the cartilage, bone, and other surrounding tissues in the knee.

  • The injection technique for administering hyaluronic acid in the knee is called intra-articular injection. The term intra-articular injection refers to an injection given directly into the joint capsule.
  • This procedure is usually done in a doctor’s office and performed by an orthopedic physician. Some rheumatologists and primary care doctors may also provide this treatment. The injection procedure takes a few minutes and usually does not involve any prior preparation. It is however advisable to discuss the medical history and current medications with the doctor prior to this treatment.
  • The use of HA injections is not advised in children, women who are pregnant or breastfeeding, or for those who have infections at the site of treatment or a known allergy to hyaluronic acid.
References
  • 1Maheu E, Rannou F, Reginster JY. Efficacy and safety of hyaluronic acid in the management of osteoarthritis: Evidence from real-life setting trials and surveys. Semin Arthritis Rheum. 2016;45(4 Suppl):S28-33.
  • 2Rutjes AW, Jüni P, Da costa BR, Trelle S, Nüesch E, Reichenbach S. Viscosupplementation for osteoarthritis of the knee: a systematic review and meta-analysis. Ann Intern Med. 2012;157(3):180-91.
  • 3Altman RD, Manjoo A, Fierlinger A, Niazi F, Nicholls M. The mechanism of action for hyaluronic acid treatment in the osteoarthritic knee: a systematic review. BMC Musculoskelet Disord. 2015;16:321. Published 2015 Oct 26. doi:10.1186/s12891-015-0775-z